Song Biotechnologies, LLC is an innovative East Coast based in vivo Contract Research Organization (CRO). Our mission is to provide a full spectrum of solutions consisting of both standard and novel technologies that improve the performance and operational effectiveness of our clients and scientific collaborators. Our research focus is on in vivo cardiovascular and microcirculatory parameters; though we have ex vivo and in vitro capabilities as well.
Song Biotechnologies, LLC provides the research community direct access to the highest level of in vivo microcirculatory analysis through trans- and epi-illumination techniques.
In vivo experimentation provides a customizable platform for robust data collection. Continuous measurements of animal physiology paired with discrete biomarker sampling work to create an elegant description of how experimental intervention affects systems biology from the macro to the micro-scale.
Breeding capabilities, sterile survival surgical expertise, and an in-house vivarium support longitudinal observational, sampling, and end point studies for a variety of experimental needs. Day and night cycling, feed selection, sociability, around the clock care, and more can be customized to study needs.
We have published a new manuscript in Artifical Cells, Nanomedicine, and Biotechnology, titled "Novel transdermal curcumin therapeutic preserves endothelial barrier function in a high-dose LPS rat model"
We have published a new manuscript in Artifical Cells, Nanomedicine, and Biotechnology, titled "Gavage approach to oxygen supplementation with oxygen therapeutic Ox66™ in a hypoventilation rodent model of respiratory distress"
We have published a new manuscript in Physiological Reports, titled "Spike of interstitial PO2 produced by a twitch in rhythmically contracted muscle"
We have published a new manuscript in the Artifical Cells, Nanomedicine, and Biotechnology, titled "Systemic and microvascular comparison of Lactated Ringer's solution, VIR-HBOC, and alpha-alpha crosslinked haemoglobin-based oxygen carrier in a rat 10% topload model"
We have published a new manuscript in the Journal of Applied Physiology, titled "Physiological and Microvascular Responses to Hemoglobin Concentration-Targeted Hemolytic Anemia in Rats"
We have published a new manuscript in Military Medicine, titled "Improved Hemodynamic Recovery and 72-Hour Survival Following Low-Volume Resuscitation with a PEGylated Carboxyhemoglobin in a Rat Model of Severe Hemorrhagic Shock"
This video demonstrates leukocyte rolling and adhesion of the exteriorized rat spinotrapezius muscle.
This video demonstrates rheological reflux where arteriolar blood flow changes due to differences in pressure.
Vasospasm - sudden constriction of an artery or arteriole, which reduces blood flow and can occasionally cause reversal in flow.